What is a consideration for patients starting treatment with azole antifungals?

Patients starting treatment with azole antifungals need to be aware of the potential for drug interactions. Azole antifungals, such as fluconazole, itraconazole, and voriconazole, can affect the metabolism of various other medications due to their influence on liver enzymes, particularly cytochrome P450 enzymes. This can either increase or decrease the levels of co-administered drugs, which may lead to an increased risk of adverse effects or decreased therapeutic effectiveness.

Given the complexity of managing multiple medications, healthcare providers often conduct a thorough medication review prior to starting an azole antifungal treatment. This ensures that any potential interactions can be addressed and monitored appropriately. Understanding this aspect is crucial for patient safety and the effectiveness of the treatment regimen.